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. 2017 Nov 14;7:15524. doi: 10.1038/s41598-017-15916-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of LIPUS treatment on neuronal damage, inflammatory cells, cerebral water content, and BBB permeability. (a) There were no cortical cell losses or intraparenchymal hemorrhages, (b) no FJB-positive degenerative neurons, and no activated microglia or infiltrated neutrophils following 1-day or 4-day LIPUS treatment in normal brain. No significant differences were found in (c) water content, (d) BBB permeability, or (e) body weight between sham brain and LIPUS-treated sham brain (n = 6).