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. 2017 Nov 14;7:15524. doi: 10.1038/s41598-017-15916-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of LIPUS treatment on cortical contusion volume in TBI mice. Representative cresyl violet-stained brain sections at (a) 1 (n = 8), (b) 4 (n = 7), and (c) 28 (n = 6) days post-TBI. Quantification revealed significantly smaller contusion volumes, residual tissue ratio and hemispheric enlargement in LIPUS-treated mice compared with non-treated mice at 1 and 4 days and significantly smaller contusion volumes and higher residual tissue ratio in LIPUS-treated mice compared with non-treated mice at 28 days. ^#Denotes significantly different from non-treated TBI group (^# p < 0.05; ^## p < 0.01; ^### p < 0.001).