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. 2017 Nov 14;27:61. doi: 10.1038/s41533-017-0061-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Simplified structural equation models identifying a predictors of adherence, healthcare seeking and asthma control, and b predictors of preference for once-daily vs. twice-daily treatment. ACT, Asthma Control Test™; ATIQ, Asthma Treatment Intrusiveness Questionnaire; BMQ, Beliefs about Medicines Questionnaire; MARS, Medication Adherence Report Scale. a Simplified structural equation model of association between adherence barriers, adherence, healthcare seeking, asthma control and asthma severity. All paths represent standardised regression weights of latent variables, corrected by bootstrapping, and are significant at P = 0.01. Paths with a positive score have a positive impact of the connected variables, while negative scores indicate negative impacts. b Simplified structural equation model of predictors of preference for once-daily vs. twice-daily treatment. All paths represent standardised regression weights of latent variables, corrected by bootstrapping, and are significant at P = 0.01. Positive paths are equivalent to an increased preference for twice-daily medication. Negative paths mean an increased preference for once-daily medication. ACT, Asthma Control Test™; ATIQ, Asthma Treatment Intrusiveness Questionnaire; BMQ, Beliefs about Medicines Questionnaire; MARS, Medication Adherence Report Scale