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. 2017 Nov 14;7:15495. doi: 10.1038/s41598-017-15707-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The relative difference in edge length distributions of the minimum spanning tree diagram and of the first level MSC clusters in the GPCR network. The length distribution of the minimum spanning tree includes both intra- and inter-cluster edges, whilst that of MSC clusters only includes intra-cluster edges. The difference is contributed from inter-cluster edges. The threshold distance between clusters is chosen to be 10⁻⁸⁰, where the value of P _all/P _intra −1 is nonzero and increases sharply.