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. 2017 Nov 14;7:15495. doi: 10.1038/s41598-017-15707-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The minimum spanning tree diagram of the 620 level 1 MSC clusters for the GPCR network in the target dataset. Here each circle represents an MSC cluster the color of which is according to the color scheme in Figs 5 and S1. The length of edges is not proportional to their distance, but the distances between subfamilies and classes are labeled to see their sequence similarity.