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. 2017 Nov 14;7:15574. doi: 10.1038/s41598-017-15773-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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UV irradiation of mouse skin induced nuclear translocation of GR and modulated the expression levels of its target genes. (a) Representative immunohistochemical images of GR-positive cells under 200x (upper panel) and high magnification (lower panel) of insert area in the hippocampus. Scale bars: 100 µm and 50 µm, respectively. The graphs show (b) GR-positive cell numbers counted in 8 brain sections from each mouse. (c) Relative GR, ARRB2, and TTP mRNA expression levels in the hippocampus were analyzed using RT-qPCR and normalized to GAPDH expression levels. Graphs show means ± SEM (n = 8mice/group). *P < 0.05 and ***P < 0.001 indicate significant differences between groups. ARRB2, arrestin beta 2; GR, glucocorticoid receptor; TTP, tristetraproline.