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. 2017 Nov 14;7:15574. doi: 10.1038/s41598-017-15773-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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UV irradiation of mouse skin results in depression-like behavior. To assess a depression-like phenotype (immobility) in UV-irradiated mice, we performed the tail suspension test. UV light was applied to the dorsal skin under anesthesia 3 days a week for 2 or 6 weeks, and the immobility time was measured during the 6 min test session and compared with that of sham-irradiated mice. Graphs show means ± SEM (n = 8 mice/group). *P < 0.05, indicate significant differences compared with control group values. Cont., Sham-UV irradiated group; 2w, 2 weeks UV-irradiated group; 6w, 6 weeks UV-irradiated group.