Table 3.

Relationship among thermogenic-, beige- and white fat- marker genes with all other gene categories in eAT, mAT and sAT biopsies.

	Thermogenesis	Beige	White
eAT
Thermogenesis
Beige
White
ECM
Immune		2.95 ± 1.14* (14.2%)
Oxidative stress	−4.41 ± 1.40** (25.6%)	4.84 ± 1.0*** (49.70%)
AT growth & function			−4.58 ± 0.11*** (45.7%)
Total variance	36.10%	63.90%	52.40%
mAT
Thermogenesis		3.53 ± 1.05** (7.60%)	3.15 ± 1.30* (9.30%)
Beige	4.90 ± 1.43** (20%)		−4.67 ± 1.36** (23.3%)
White	3.46 ± 1.43* (8.60%)	−4.05 ± 1.16** (10%)
ECM
Immune
Oxidative stress	−2.93 ± 1.31* (8.7%)	7.43 ± 1.00*** (47.50%)	2.73 ± 1.25* (9.80%)
AT growth & function	−3.92 ± 1.14** (16.6%)		−3.34 ± 1.12** (15.7%)
Total variance	54%	67.80%	58%
sAT
Thermogenesis
Beige
White
ECM
Immune	4.34 ± 0.94*** (33.70%)
Oxidative stress
AT growth & function	4.92 ± 0.78*** (46.70%)		3.63 ± 0.89*** (45.60%)
Total variance	83.50%		55.40%

Values represent stepwise regression coefficient estimate ± SE (% variance for each category) for various functional gene categories for each fat depot, n = 53. Relationships among these groups of genes (categorized in Table 2) were assessed using principal component analysis followed by stepwise regression as described in the methods section. *Represents P ≤ 0.05, **represents P ≤ 0.01, ***represents P ≤ 0.001. ECM: extracellular matrix; AT: Adipose tissue.