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. 2017 Nov 14;7:15518. doi: 10.1038/s41598-017-15822-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification and characterization of the eRNA regions in hESCs. (A) UCSC browser display of epigenetic signatures, transcription factors, coactivators, and transcription status for a representative locus in chr1: 24,455,067-24,654,494. The red rectangle indicates an eRNA region, and blue rectangles indicate weakly-transcribed regions. (B) Metagene representations of the mean multi-omic signature signal for DNase I, RNAPII, histone modifications, RNA-seq, and chromatin regulators across eRNA regions (red) and weakly-transcribed enhancers (blue) regions. Metagenes are centred on the eRNA regions (5,863 bp and 11,890 bp for weakly-transcribed enhancers and enhancer RNA regions, respectively) with 5 kb on both sides of each enhancer region.