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. 2017 Nov 14;7:15501. doi: 10.1038/s41598-017-15825-4

Figure 1.

Figure 1

Lcn2 KO mice were resistant against diet-induced obesity. (a) Lcn2 mRNA expression levels in liver, subcutaneous (sub) WAT, mesenteric (mes) WAT and interscapular BAT at 24 weeks after HFD or ND feeding in WT mice (n = 4). Allocation to HFD or ND was carried out at 8 weeks of age. Lcn2 expression level was normalized for 18 S ribosomal RNA expression. The level in Mes WAT given ND was defined as 1.0. *P < 0.05, **P < 0.01 vs ND. (b) Body weights of KO and WT mice treated with ND or HFD since 8 weeks of age (n = 9). *P < 0.05 between KO and WT mice. #P < 0.05 vs 0 week. (c) Organ weights of KO and WT mice treated with ND or HFD for 24 weeks (n = 5–6). *P < 0.05 between KO and WT mice. *P < 0.05 vs WT. #P < 0.01 vs ND. (d) Daily food intake of KO and WT mice (n = 6). *P < 0.05 between KO and WT mice. Data are expressed as mean ± SEM.