Figure 4.
Thermogenic genes were activated in BAT, but neither blood pressure nor urinary noradrenaline level was elevated by HFD in Lcn2 KO mice. (a) Ppargc1a, Ucp1 and Dio2 mRNA expression levels in interscapular BAT at 24 weeks after HFD or ND feeding in KO and WT mice (n = 5). The level in WT mice given ND was defined as 100(%). #P < 0.05 vs ND. *P < 0.05 between KO and WT mice. (b) Systolic and diastolic blood pressures of KO and WT mice treated with HFD or ND (n = 6). (c) Daily urinary excretion of noradrenalin and adrenalin (n = 4). #P < 0.05 vs 0 week. *P < 0.05 between KO and WT mice.