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. 2017 Nov 14;7:15501. doi: 10.1038/s41598-017-15825-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cold tolerance in Lcn2 KO mice was canceled by β3 adrenergic receptor antagonist or by iron-loaded LCN2. (a) Thermogenic gene expression in BAT was activated by cold exposure in KO and WT mice (n = 4–5). ^#P < 0.05 vs 23 °C. (b) Effects of β3 adrenergic receptor antagonist SR59230A (SR) upon cold tolerance in KO mice (n = 4). *P < 0.05 between KO:vehicle and WT: vehicle mice. (c) Effects of LCN2:siderophore:iron complex upon cold tolerance in KO mice (n = 8). The complex was injected intraperitoneally 15 min before cold exposure. *P < 0.05.