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. 2017 Nov 14;7:15528. doi: 10.1038/s41598-017-14764-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LRP1 reversed impaired pro-carcinogenic function in melanoma cell with YAP-KD. (a) Cell proliferation in melanoma A375 cells was measured by MTT assays when transfected with different expressing plasmids as indicated. (b) Caspase 3/7 activities in melanoma A375 cells were measured when transfected with different expressing plasmids as indicated. (c,d) Transwell activity in melanoma A375 cells was measured by transwell assay when transfected with different expressing plasmids as indicated. (e) Cell proliferation in melanoma MUM-2B cells was measured by MTT assays when transfected with different expressing plasmids as indicated. (f) Caspase 3/7 activities in melanoma MUM-2B cells were measured when transfected with different expressing plasmids as indicated. (g,h) Transwell activity in melanoma MUM-2B cells was measured by transwell assays when transfected with different expressing plasmids as indicated. Data were shown as mean ± SD from three independent experiments. *P < 0.05; **P < 0.01 versus control measured by the student t test.