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. 2017 Nov 14;7:15528. doi: 10.1038/s41598-017-14764-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Possible mechanisms underlying how YAP regulated LRP1 by promoting proliferation and metastasis of melanoma cells and also reducing apoptosis. These pathways are involved in several processes of tumorigenesis and progression. Yes-associated Protein (YAP) can stimulate the expression of Low-density lipoprotein receptor-related protein 1(LRP1) via binding to the LRP1-promoter.LRP1 can activates the mitogen-activated protein kinase signaling pathway (MAPK), which can increase the transcriptional levels of matrix metalloproteinase (MMP)2 and MMP9. MMP2/9 can drive cancer cell proliferation and invasion.LRP1 activates the serine/threonine protein kinase (AKT) signaling pathway and insulin receptor (IR), which inhibits cancer cell apoptosis.