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. 2017 Nov 14;7:15528. doi: 10.1038/s41598-017-14764-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LRP1 reversed impaired pro-carcinogenic function in vivo with YAP-KD. (a) A375 melanoma cells and MUM-2B melanoma cells (2 × 10⁵) were transfected with GFP-sh or YAP-sh or YAP-sh + LRP1-FLAG and then injected subcutaneously to athymic nude mice (n = 5 for each group). Three weeks later, cohorts of mice from each group were sacrificed to determine the tumor volume, the in vivo experiment was repeated twice. (b) Representation (up) and quantification (down) of xenograft tumors formed by subcutaneous injection of A375 melanoma cells stably transfected with YAP-sh plasmids or infected with YAP-sh + LRP1-FLAG plasmids. (c) Representation (up) and quantification (down) of xenograft tumors formed by subcutaneous injection of MUM-2B melanoma cells stably transfected with YAP-sh plasmids or infected with YAP-sh + LRP1 plasmids. *P < 0.05; **P < 0.01; ***P < 0.001 versus control measured by the student t test.