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. 2017 Oct 19;80(6):1171–1178. doi: 10.1007/s00280-017-3463-x

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Kaplan–Meier plot of progression free survival (weeks) in a pooled analysis of both renal cell carcinoma and soft tissue sarcoma patients with an average C_min above (n = 51, solid line) or below (n = 10, dashed line) the exposure target of > 20 mg/L. Median progression free survival was 25.0 weeks for patients with high and 8.80 weeks for patients with low exposure, p = 0.012 (log-rank test)