Table 4.

Factors proposed to define complex phase PD

Combination of motor and NMS grading using a combined grading system (HY + NMSSB or HY + NMSQB)

Falling or failing response to oral/transdermal DRT therapy with emergence of motor and nonmotor fluctuations

Datscan showing low (dependent on local laboratory estimates) putamen or combined putamen and caudate binding ratios

Accelerometry based dataset indication and supporting clinical impression of severe bradykinesia or troublesome dyskinesia at home. (Additionally some nonmotor data may also become available such as an indication of sleep function)

Presence of personality trait based factors necessitating the delivery personalised medicine

HY Hoehn and Yahr, NMSSB nonmotor symptoms scale derived burden, NMSQB nonmotor symptoms questionnaire based burden