Table 3.

Study characteristics and patient demographics

Reference	Number of patients	Study type	Article location	Mean age (years)	Patient characteristics	Primary and secondary goal of study
Positive association studies
Filippou et al. [23]	6	Prospective observational	Meeting abstract	Unknown	Severe TBI	Primary: CMD measures and MRS/ADC imaging Secondary: None stated
Marcoux et al. [53]	15	Retrospective case series	Manuscript	30.1 years (range, 18–58)	Severe TBI	Primary: Determine association between CMD-based metabolic dysfunction and long-term tissue atrophy Secondary: Determine association with long-term outcome
Nil association studies
Filippou et al. [22]	10	Prospective observational	Meeting abstract	Unknown	Severe TBI	Primary: Determine CMD measure correlation to MRS/ADC Secondary: None mentioned
Stein et al. [89]	21	Prospective observational	Meeting abstract	Unknown	Severe TBI	Primary: To determine if CMD defined metabolic crisis (LPR > 25; glucose <0.8 mmol/l) correlates with MRI-based ADC changes

TBI traumatic brain injury, CMD cerebral microdialysis, LPR lactate:pyruvate ratio, MRS magnetic resonance spectroscopy, MRI magnetic resonance imaging, ADC apparent diffusion coefficient