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. 2017 Nov 18;10(11):1640–1646. doi: 10.18240/ijo.2017.11.02

Table 4. Comparison of the histopathologic findings of the keratoconus corneas according to the keratoconus severity.

Findings Stage 1 Stage 2 Stage 3 Stage 4 P1
Epithelial thinning
 With 0 (0.0) 11 (33.3) 10 (30.3) 12 (36.4) <0.001
 Without 1 (50.0) 1 (50.0) 0 (0.0) 0 (0.0)
Breaks in the Bowman's layer
 With 0 (0.0) 9 (31.0) 8 (27.6) 12 (41.4) 0.048
 Without 1 (16.7) 3 (50.0) 2 (33.3) 0 (0.0)
Folds in Descemet's membrane
 With 0 (0.0) 1 (6.7) 7 (46.7) 7 (46.7) 0.013
 Without 1 (5.0) 11(55.0) 3 (15.0) 5 (25.0)
Stromal fiber compaction
 With 0 (0.0) 3 (21.4) 4 (28.6) 7 (50.5) 0.324
 Without 1 (4.8) 9 (42.9) 6 (28.6) 5 (23.8)
Superficial iron deposition
 With 0 (0.0) 2 (16.7) 6 (50.0) 4 (33.3) 0.164
 Without 1 (4.3) 10 (43.5) 4 (17.4) 8 (34.8)
Collagen filling in Bowman's layer
 With 0 (0.0) 2 (18.2) 4 (36.4) 5 (45.5) 0.458
 Without 1 (4.2) 10 (41.7) 6 (25.0) 7 (29.1)
Epithelial scars
 With 0 (0.0) 0 (0.0) 2 (20.0) 8 (80.0) 0.003
 Without 1 (4.0) 12 (48.0) 8 (32.0) 4 (16.0)
Breaks in Descemet's membrane
 With 0 (0.0) 1 (11.1) 3 (33.3) 5 (55.6) 0.268
 Without 1 (3.8) 11 (42.3) 7 (26.9) 7 (26.9)
Stromal scars
 With 0 (0.0) 0 (0.0) 1 (12.5) 7 (87.5) 0.004
 Without 1 (3.7) 12 (44.4) 9 (33.3) 5 (18.5)
Endothelial cell loss
 With 0 (0.0) 4 (57.1) 3 (42.9) 0 (0.0) 0.157
 Without 1 (3.6) 8 (28.6) 7 (25.0) 12 (42.9)

1 Chi-square or Fischer's exact test.

n (%)