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. 2017 Nov 12;4:598–613. doi: 10.1016/j.toxrep.2017.11.002

Table 2.

Summary of Locomotor Activity Data.

Male Rats
Group Dose mg/kg bw/day Total distance travelled (m) Average speed (m/s) Absolute turn angle (°) Rotations of the animal's body Absolute head turn angle (°)
Vehicle Control − (0.5% (w/v) Carboxymethyl Cellulose, aqueous)
G1 & G1 (R) 0 Mean 8.784 0.015 6930 6.8 10040
± S. D. 5.201 0.009 4409 4.9 4882
n 15 15 15 15 15
Test Item: Citrus aurantium Extract 50% p-Synephrine
G2 100 Mean 11.355 0.019 8332 8.0 10306
± S. D. 4.820 0.008 2528 4.2 4294
n 10 10 10 10 10
G3 300 Mean 11.224 0.019 11111 9.4 15295S+
± S. D. 2.782 0.005 4160 3.3 6098
n 10 10 10 10 10
G4 & G4 (R) 1000 Mean 8.925 0.015 8640 7.5 12580
± S. D. 6.591 0.011 5030 5.8 5489
n 15 15 15 15 15
S+/S-: Group mean value is significantly (P < 0.05) higher/lower than the respective value of the vehicle control group. Animals were assessed on days 87 and 88. The duration of the test was 600 s.
Female Rats
Group Dose mg/kg bw/day Total distance travelled (m) Average speed (m/s) Absolute turn angle (°) Rotations of the animal's body Absolute head turn angle (°)
Vehicle Control − (0.5% (w/v) Carboxymethyl Cellulose, aqueous)
G1 & G1 (R) 0 Mean 17.928 0.030 16103 15.7 20126
± S. D. 3.716 0.006 2638 3.8 1888
n 15 15 15 15 15
Test Item: Citrus aurantium Extract 50% p-Synephrine
G2 100 Mean 18.849 0.031 15821 15.4 20266
± S. D. 1.506 0.002 2345 3.0 1081
n 10 10 10 10 10
G3 300 Mean 17.441 0.029 15796 12.6 19290
± S. D. 2.460 0.004 5978 2.0 1401
n 10 10 10 10 10
G4 & G4 (R) 1000 Mean 18.891 0.032 16646 16.5 21225
± S. D. 5.601 0.009 3117 4.7 2612
n 15 15 15 15 15
Group mean values of treated groups do not differ significantly (P > 0.05) from those of the respective values of the vehicle control group. Animals were assessed on days 87 and 88. The duration of the test was 600 s.