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. 2017 Nov 12;4:598–613. doi: 10.1016/j.toxrep.2017.11.002

Table 3.

Summary of Absolute Organ Weights (g) at Termination (Day 91).

Male Rats
Group Dose mg/kg/day Fasting Body Wt. Adrenals Testes Kidneys Liver Brain Thymus Heart Spleen Epididymides
Vehicle Control − 0.5% (w/v) Carboxymethyl cellulose, aqueous only
G1 0 Mean 456.00 0.055 3.90 3.14 13.22 2.41 0.43 1.63 0.83 1.55
S. D 46.68 0.007 0.31 0.35 1.83 0.16 0.10 0.17 0.13 0.19
n 10 10 10 10 10 10 10 10 10 10
Test Item: Citrus aurantium 50% p-synephrine
G2 100 Mean 469.20 0.050 3.93 3.12 12.93 2.38 0.53 1.66 0.85 1.59
S. D 35.12 0.012 0.33 0.36 1.46 0.13 0.17 0.16 0.08 0.22
n 10 10 10 10 10 10 9 10 10 10
G3 300 Mean 462.90 0.052 3.71 3.21 13.47 2.38 0.51 1.65 0.86 1.46
S. D 18.78 0.014 0.38 0.35 1.05 0.11 0.17 0.14 0.08 0.18
n 10 10 10 10 10 10 10 10 10 10
G4 1000 Mean 433.60 0.055 3.53 3.24 12.80 2.28 0.36S− 1.76 1.01 1.39
S. D 38.57 0.018 0.58 0.82 1.29 0.11 0.09 0.26 0.43 0.19
n 10 10 10 10 10 10 10 10 10 10
Female Rats
Group Dose mg/kg/day Fasting Body Wt. Adrenals Ovaries Kidneys Liver Brain Thymus Heart Spleen Uterus
Vehicle Control − 0.5% (w/v) Carboxymethyl cellulose, aqueous only
G1 0 Mean 278.60 0.064 0.127 1.87 7.53 2.18 0.39 1.10 0.69 0.77
S. D 23.30 0.017 0.016 0.20 0.79 0.11 0.09 0.11 0.10 0.33
n 10 10 10 10 10 10 10 10 10 10
Test Item: Citrus aurantium 50% p-synephrine
G2 100 Mean 289.00 0.074 0.134 2.05 7.76 2.16 0.38 1.12 0.66 0.72
S. D 24.34 0.026 0.027 0.15 0.51 0.13 0.08 0.09 0.07 0.17
n 10 10 10 10 10 10 10 10 10 10
G3 300 Mean 273.80 0.075 0.117 2.01 7.56 2.22 0.35 1.14 0.65 0.72
S. D 23.13 0.016 0.023 0.30 0.91 0.11 0.06 0.09 0.12 0.33
n 10 10 10 10 10 10 10 10 10 10
G4 1000 Mean 280.30 0.076 0.130 2.06 8.13 2.19 0.39 1.19 0.69 0.76
S. D 26.92 0.016 0.034 0.30 1.06 0.13 0.08 0.13 0.11 0.30
n 10 10 10 10 10 10 10 10 10 10

S-: Group mean value is significantly (P < 0.05) lower than the respective value of the vehicle control group.

Group mean values of treated rats do not differ significantly (P > 0.05) from those of the control group.