Table 3.
Male Rats | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Group | Dose mg/kg/day | Fasting Body Wt. | Adrenals | Testes | Kidneys | Liver | Brain | Thymus | Heart | Spleen | Epididymides | |
Vehicle Control − 0.5% (w/v) Carboxymethyl cellulose, aqueous only | ||||||||||||
G1 | 0 | Mean | 456.00 | 0.055 | 3.90 | 3.14 | 13.22 | 2.41 | 0.43 | 1.63 | 0.83 | 1.55 |
S. D | 46.68 | 0.007 | 0.31 | 0.35 | 1.83 | 0.16 | 0.10 | 0.17 | 0.13 | 0.19 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
Test Item: Citrus aurantium 50% p-synephrine | ||||||||||||
G2 | 100 | Mean | 469.20 | 0.050 | 3.93 | 3.12 | 12.93 | 2.38 | 0.53 | 1.66 | 0.85 | 1.59 |
S. D | 35.12 | 0.012 | 0.33 | 0.36 | 1.46 | 0.13 | 0.17 | 0.16 | 0.08 | 0.22 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 10 | 10 | 10 | ||
G3 | 300 | Mean | 462.90 | 0.052 | 3.71 | 3.21 | 13.47 | 2.38 | 0.51 | 1.65 | 0.86 | 1.46 |
S. D | 18.78 | 0.014 | 0.38 | 0.35 | 1.05 | 0.11 | 0.17 | 0.14 | 0.08 | 0.18 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G4 | 1000 | Mean | 433.60 | 0.055 | 3.53 | 3.24 | 12.80 | 2.28 | 0.36S− | 1.76 | 1.01 | 1.39 |
S. D | 38.57 | 0.018 | 0.58 | 0.82 | 1.29 | 0.11 | 0.09 | 0.26 | 0.43 | 0.19 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
Female Rats | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Group | Dose mg/kg/day | Fasting Body Wt. | Adrenals | Ovaries | Kidneys | Liver | Brain | Thymus | Heart | Spleen | Uterus | |
Vehicle Control − 0.5% (w/v) Carboxymethyl cellulose, aqueous only | ||||||||||||
G1 | 0 | Mean | 278.60 | 0.064 | 0.127 | 1.87 | 7.53 | 2.18 | 0.39 | 1.10 | 0.69 | 0.77 |
S. D | 23.30 | 0.017 | 0.016 | 0.20 | 0.79 | 0.11 | 0.09 | 0.11 | 0.10 | 0.33 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
Test Item: Citrus aurantium 50% p-synephrine | ||||||||||||
G2 | 100 | Mean | 289.00 | 0.074 | 0.134 | 2.05 | 7.76 | 2.16 | 0.38 | 1.12 | 0.66 | 0.72 |
S. D | 24.34 | 0.026 | 0.027 | 0.15 | 0.51 | 0.13 | 0.08 | 0.09 | 0.07 | 0.17 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G3 | 300 | Mean | 273.80 | 0.075 | 0.117 | 2.01 | 7.56 | 2.22 | 0.35 | 1.14 | 0.65 | 0.72 |
S. D | 23.13 | 0.016 | 0.023 | 0.30 | 0.91 | 0.11 | 0.06 | 0.09 | 0.12 | 0.33 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
G4 | 1000 | Mean | 280.30 | 0.076 | 0.130 | 2.06 | 8.13 | 2.19 | 0.39 | 1.19 | 0.69 | 0.76 |
S. D | 26.92 | 0.016 | 0.034 | 0.30 | 1.06 | 0.13 | 0.08 | 0.13 | 0.11 | 0.30 | ||
n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
S-: Group mean value is significantly (P < 0.05) lower than the respective value of the vehicle control group.
Group mean values of treated rats do not differ significantly (P > 0.05) from those of the control group.