Table 7.
Summary of Hematological Data at Termination on Day 91. Male Rats.
| Male Rats | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Dose (mg/kg/day) | Hb | PCV | Total RBC | RBC Indices |
Total WBC | Differential WBC Count |
Platelets | PT | APTT | RET | General Blood Picture | |||||||
| MCH | MCV | MCHC | N | L | M | E | B | ||||||||||||
| (g/dl) | (%) | (X106/cmm) | (pg) | (fl) | (g/dl) | (X103/cmm) | % | % | % | % | % | (X103/ cmm) | (Sec) | (Sec) | (%) | ||||
| Vehicle Control: 0.5% (w/v) Carboxymethyl cellulose, aqueous | |||||||||||||||||||
| G1 | 0 | Mean | 16.05 | 46.38 | 8.61 | 18.66 | 53.90 | 34.62 | 6.30 | 21.27 | 74.53 | 0.760 | 3.451 | 0.004 | 853.10 | 17.55 | 13.35 | 1.92 | NAD |
| S. D | 0.66 | 2.21 | 0.47 | 0.45 | 1.06 | 0.34 | 1.24 | 5.72 | 5.82 | 0.333 | 1.184 | 0.009 | 50.88 | 2.67 | 1.86 | 0.45 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Test Item: Citrus aurantium 50% p-synephrine | |||||||||||||||||||
| G2 | 100 | Mean | 15.93 | 46.18 | 8.64 | 18.46 | 53.52 | 34.51 | 6.31 | 23.89 | 72.97 | 0.590 | 2.544 | 0.009 | 773.70 | 16.98 | 14.10 | 1.66 | NAD |
| S. D | 0.69 | 2.32 | 0.57 | 0.72 | 2.25 | 0.58 | 1.31 | 6.76 | 7.02 | 0.194 | 0.566 | 0.024 | 214.33 | 1.72 | 1.39 | 0.20 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| G3 | 300 | Mean | 15.90 | 45.92 | 8.51 | 18.74 | 54.16 | 34.62 | 5.43 | 28.70 | 67.52 | 0.580 | 3.232 | 0.002 | 862.00 | 19.22 | 14.11 | 1.85 | NAD |
| S. D | 0.86 | 2.30 | 0.66 | 1.21 | 3.91 | 0.63 | 0.79 | 6.67 | 6.15 | 0.226 | 1.301 | 0.008 | 69.27 | 5.46 | 1.83 | 0.42 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| G4 | 1000 | Mean | 15.29 | 44.04 | 8.22 | 18.74 | 53.98 | 34.71 | 6.24 | 22.50 | 72.91 | 0.809 | 3.741 | 0.003 | 893.00 | 18.40 | 18.17 | 2.21 | NAD |
| S. D | 1.00 | 2.68 | 0.82 | 1.86 | 5.47 | 0.55 | 1.55 | 5.03 | 5.56 | 0.650 | 1.186 | 0.007 | 126.52 | 4.06 | 13.80 | 1.15 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Values of treated rats do not differ significantly (P > 0.05) from those of the respective control group values. | |||||||||||||||||||
| Female Rats | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Dose (mg/kg/day) | Hb | PCV | Total RBC | RBC Indices |
Total WBC | Differential WBC Count |
Platelets | PT | APTT | RET | General Blood Picture | |||||||
| MCH | MCV | MCHC | N | L | M | E | B | ||||||||||||
| (g/dl) | (%) | (X106/cmm) | (pg) | (fl) | (g/dl) | (X103/cmm) | % | % | % | % | % | (X103/ cmm) | (Sec) | (Sec) | (%) | ||||
| Vehicle Control: 0.5% (w/v) Carboxymethyl cellulose, aqueous | |||||||||||||||||||
| G1 | 0 | Mean | 15.42 | 44.86 | 8.02 | 19.25 | 55.99 | 34.38 | 5.57 | 20.06 | 75.45 | 0.48 | 3.91 | 0.10 | 818.70 | 16.60 | 12.86 | 3.90 | NAD |
| S. D | 0.49 | 1.55 | 0.37 | 0.49 | 1.56 | 0.31 | 1.18 | 12.23 | 12.62 | 0.34 | 1.93 | 0.31 | 96.30 | 1.47 | 1.66 | 0.87 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| Test Item: Citrus aurantium 50% p-synephrine | |||||||||||||||||||
| G2 | 100 | Mean | 15.10 | 44.15 | 7.91 | 19.13 | 55.94 | 34.21 | 4.82 | 20.55 | 74.18 | 0.60 | 4.35 | 0.36 | 731.30 | 16.45 | 13.55 | 3.60 | NAD |
| S. D | 0.48 | 1.56 | 0.47 | 0.82 | 2.38 | 0.33 | 0.96 | 8.62 | 9.12 | 0.38 | 1.94 | 1.12 | 125.98 | 1.22 | 1.60 | 0.65 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| G3 | 300 | Mean | 15.36 | 44.76 | 7.88 | 19.50 | 56.83 | 34.32 | 4.73 | 18.75 | 75.48 | 0.96 | 4.79 | 0.00 | 812.70 | 16.49 | 12.56 | 3.66 | NAD |
| S. D | 0.50 | 1.52 | 0.27 | 0.43 | 1.28 | 0.27 | 0.62 | 5.66 | 5.48 | 0.57 | 1.22 | 0.00 | 146.66 | 1.66 | 1.68 | 1.64 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
| G4 | 1000 | Mean | 15.04 | 43.95 | 7.79 | 19.32 | 56.45 | 34.23 | 4.59 | 17.68 | 78.37 | 0.47 | 3.48 | 0.00 | 791.10 | 17.21 | 12.79 | 4.01 | NAD |
| S. D | 0.66 | 2.11 | 0.43 | 0.49 | 1.48 | 0.34 | 0.63 | 2.80 | 3.62 | 0.36 | 1.68 | 0.00 | 89.85 | 1.20 | 1.94 | 1.34 | – | ||
| n | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||
Values of treated rats do not differ significantly (P > 0.05) from those of the respective control group values.
Hb-hemoglobin; PCV-hematocrit (packed cell volume); RBC-red blood cells; MCH-mean corpuscular hemoglobin; MCV-mean corpuscular volume; MCHC- mean corpuscular hemoglobin concentration; WBC-white cell count; N-neutrophils; L-leukocytes; M-monocytes; E-eosinophils; B-basphils; PT–prothrombin time; APTT- activated partial thromboplastin time; RET-reticulocyte count.