Table 8.
Summary of Hematology Data at Termination of Recovery Period (Day 119).
| Male Rats | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Dose (mg/kg/day) | Hb | PCV | Total RBC | RBC Indices |
Total WBC | Differential WBC Count |
Platelets | PT | APTT | RET | General Blood Picture | ||||||||
| MCH | MCV | MCHC | L | M | E | B | ||||||||||||||
| (g/dl) | (%) | (X106/cmm) | (pg) | (fl) | (g/dl) | (X103/cmm) | % | % | % | % | % | (X103/ cmm) | (Sec) | (Sec) | (%) | |||||
| Vehicle Control: 0.5% (w/v) Carboxymethyl cellulose, aqueous | ||||||||||||||||||||
| G1 (R) | 0 | Mean | 15.30 | 43.80 | 8.06 | 19.01 | 54.40 | 34.93 | 5.20 | 26.08 | 69.92 | 0.332 | 3.686 | 2.500 | 591.40 | 16.40 | 14.28 | 2.70 | NAD | |
| S. D | 0.58 | 1.72 | 0.54 | 0.71 | 1.59 | 0.42 | 1.36 | 7.24 | 6.79 | 0.162 | 0.921 | 5.590 | 311.74 | 0.87 | 1.69 | 0.28 | – | |||
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||
| Test Item: Citrus aurantium 50% p-synephrine | ||||||||||||||||||||
| G4 (R) | 1000 | Mean | 15.76 | 44.98 | 8.56 | 18.42 | 52.58 | 35.04 | 6.40 | 26.22 | 69.74 | 0.766S+ | 3.262 | 0.000 | 871.00 | 17.44 | 14.10 | 2.45 | NAD | |
| S. D | 0.62 | 1.97 | 0.30 | 0.53 | 1.89 | 0.35 | 1.02 | 6.46 | 6.48 | 0.273 | 0.599 | 0.000 | 40.02 | 0.83 | 2.00 | 0.68 | – | |||
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||
| Female Rats | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Dose (mg/kg/day) | Hb | PCV | Total RBC | RBC Indices |
Total WBC | Differential WBC Count |
Platelets | PT | APTT | RET | General Blood Picture | ||||||||
| MCH | MCV | MCHC | N | L | M | E | B | |||||||||||||
| (g/dl) | (%) | (X106/cmm) | (pg) | (fl) | (g/dl) | (X103/cmm) | % | % | % | % | % | (X103/ cmm) | (Sec) | (Sec) | (%) | |||||
| Vehicle Control: 0.5% (w/v) Carboxymethyl cellulose, aqueous | ||||||||||||||||||||
| G1 (R) | 0 | Mean | 15.54 | 44.14 | 6.91 | 25.39 | 72.05 | 35.21 | 4.52 | 23.92 | 71.74 | 0.285 | 4.042 | 0.017 | 846.80 | 17.14 | 13.30 | 2.32 | NAD | |
| S. D | 0.38 | 1.08 | 2.06 | 12.31 | 34.62 | 0.15 | 0.80 | 3.75 | 4.19 | 0.164 | 1.500 | 0.024 | 82.21 | 0.95 | 2.44 | 1.81 | – | |||
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||
| Test Item: Citrus aurantium 50% p-synephrine | ||||||||||||||||||||
| G4 (R) | 1000 | Mean | 15.46 | 44.72 | 8.13 | 19.07 | 55.07 | 34.61 | 4.57 | 15.20S− | 80.22S+ | 0.508S+ | 4.080 | 0.005 | 714.40 | 17.60 | 13.94 | 1.75 | NAD | |
| S. D | 0.66 | 2.36 | 0.53 | 1.17 | 1.57 | 1.46 | 0.82 | 4.26 | 4.64 | 0.119 | 1.562 | 0.010 | 181.14 | 1.09 | 0.83 | 0.46 | – | |||
| n | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||
S+/S-: Group mean value is significantly (P < 0.05) higher/lower than the respective control group value.
Hb-hemoglobin; PCV-hematocrit (packed cell volume); RBC-red blood cells; MCH-mean corpuscular hemoglobin; MCV-mean corpuscular volume; MCHC- mean corpuscular hemoglobin concentration; WBC-white cell count; N-neutrophils; L-leukocytes; M-monocytes; E-eosinophils; B-basphils; PT–prothrombin time; APTT- activated partial thromboplastin time; RET-reticulocyte count.
Values of treated rats do not differ significantly (P > 0.05) from those of the respective control group values.