Figure 4.

HMGCS1 and HMGCR promote prostate cancer cell proliferation through paracrine regulation. (A and B) In vitro growth curves (mean ± SE) revealed that 22Rv1 cells co-cultured with HMGCS1- or HMGCR-overexpressing PrSC cells (transfected with HMGCS1 or HMGCR expression vectors), grew more rapidly than those co-cultured with PrSC mock transfectants. Experiments were carried out in triplicate with statistical analysis performed by Student's t-test (*P<0.01). HMGCS1, 3-hydroxy-3-methylglutaryl-CoA synthase 1; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase.