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Effects of flumazenil on KRM-II-18B- and KRM-II-81-induced antinociception. Bars represent the mean and error bars show S.E.M. (n = 6–8 per group). Abscissa: pretreatment groups. Ordinate: total number of writhes induced by 0.32% lactic acid. A) KRM-II-18B pretreatment alone and with flumazenil. B) KRM-II-81 pretreatment alone and with flumazenil. Asterisks indicate significant difference in number of writhes in the presence and absence of flumazenil. *P < 0.05, ***p < 0.001.
