Figure 5.
Diagram summarizing the role of CDO1 during erastin-induced ferroptosis.
Erastin inhibits cellular cysteine uptake by suppressing system XC− and depleting GSH. This leads to inactivation of GPX4, increased ROS, and subsequently ferroptosis. CDO1, transcriptionally regulated by c-Myb, can transform cysteine to taurine and thereby competitively deprive cells of the cysteine used to synthesize GSH. When CDO1 expression is inhibited, the conversion of cysteine to taurine is decreased, enhancing GSH generation. Therefore, GPX4 activity is promoted, inhibiting ROS accumulation and lipid peroxidation and ultimately reducing the risk of ferroptosis.