Table 3. DAVID 6.7 Analysis.
| Gene list input | Gene counts | Percent of input list | Fold enrichments over background | Bonferroni corrected p-values |
|---|---|---|---|---|
| (A) Novel L1s—with overlapping genes | Schizophrenia (Normal) | |||
| GO_cellular compartment_FAT | ||||
| GO:0042995~cell projection | 18 (NA) | 11.76 (NA) | 3.03 (NA) | 0.0151 (NA) |
| (B) Novel L1s—no overlapping genes | ||||
| GO_cellular compartment_FAT | ||||
| GO:0042995~cell projection | 13 (NA) | 15.12 (NA) | 3.91 (NA) | 0.0133 (NA) |
| (C) KNR L1s—with overlapping genes | ||||
| GO_cellular compartment_FAT | ||||
| GO:0044459~plasma membrane part | 42 (NA) | 21.88 (NA) | 1.81 (NA) | 0.0242 (NA) |
| GO:0005886~plasma membrane | 61 (NA) | 31.77 (NA) | 1.53 (NA) | 0.0314 (NA) |
| GO:0043005~neuron projection | 17 (18) | 8.85 (8.53) | 4.71 (4.43) | 1.43E−04 (1.53E−04) |
| GO:0045202~synapse | 16 (16) | 8.33 (7.58) | 4.27 (3.79) | 1.16E−03 (5.17E−03) |
| GO:0030054~cell junction | 18 (19) | 9.38 (9.00) | 3.29 (3.08) | 7.28E−03 (0.0103) |
| GO:0042995~cell projection | 21 (22) | 10.94 (10.43) | 2.85 (2.65) | 9.43E−03 (0.0182) |
| (D) KNR L1s—no overlapping genes | ||||
| No significant GO terms identified | NA (NA) | NA (NA) | NA (NA) | NA (NA) |
| (E) Novel+KNR L1s—no overlapping genes | ||||
| GO_biological process_FAT | ||||
| GO:0042981~regulation of apoptosis | NA (15) | NA (16.30) | NA (3.55) | NA (0.0470) |
| GO_cellular compartment_FAT | ||||
| GO:0045202~synapse | 11 (NA) | 9.57 (NA) | 4.95 (NA) | 0.0120 (NA) |
Abbreviations: FAT, filtered annotated terms; GO, Gene Ontology; KNR, known non-reference; NA, not applicable.
‘Overlapping genes’ refers to genes harboring L1s found in both the normal and schizophrenia populations.