Table 2. Summary of Significant Findings from Regression Analyses in the Discovery Sample.
| rs ID | Test | Sample | n | Mean (SD) |
Bootstrap 95 CI |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| r2 | B | Lower | Upper | P | |||||||
| AA (n=251) | AG (n=330) | GG (n=133) | |||||||||
| CACNA1C | All | 714 | 35.17 (23.10) | 37.43 (25.55) | 41.61 (23.44) | 0.006 | 2.600 | 0.635 | 4.535 | 0.012* | |
| rs2007044 | SWM | Broad | 557 | 38.82 (19.93) | 41.91 (26.75) | 47.51 (21.30) | 0.012 | 3.634 | 1.133 | 6.184 | 0.006** |
| SZ/SZA | 409 | 40.72 (22.66) | 43.38 (25.76) | 49.94 (21.25) | 0.011 | 3.578 | 0.717 | 6.153 | 0.013* | ||
| Healthy | 157 | 15.73 (12.27) | 18.23 (16.42) | 21.27 (17.31) | 0.010 | 2.102 | −0.632 | 4.891 | 0.138 | ||
| GG (n=6) | GT (n=97) | TT (n=416) | |||||||||
| CACNB2 | All | 519 | 17.17 (1.72) | 16.43 (2.20) | 15.66 (3.25) | 0.012 | −0.772 | −1.210 | −0.337 | 0.003** | |
| rs7893279 | Hinting Task | Broad | 380 | 16.25 (0.96) | 16.00 (2.37) | 15.34 (3.55) | 0.006 | −0.643 | −1.203 | −0.122 | 0.021* |
| SZ/SZA | 295 | 16.33 (1.15) | 16.02 (2.38) | 15.15 (3.74) | 0.009 | −0.826 | −1.553 | −0.147 | 0.017* | ||
| Healthy | 139 | 19.00 (1.41) | 17.31 (1.51) | 16.59 (1.87) | 0.052 | −0.895 | −1.448 | −0.282 | 0.005** | ||
| TT (n=63) | TC (n=266) | CC (n=224) | |||||||||
| RIMS1 | All | 553 | 22.56 (6.36) | 22.32 (6.17) | 23.51 (5.83) | 0.008 | 0.831 | 0.300 | 1.568 | 0.024* | |
| rs1339227 | Eyes Test | Broad | 392 | 20.20 (6.12) | 20.51 (6.25) | 22.48 (6.14) | 0.018 | 1.272 | 0.235 | 2.228 | 0.007** |
| SZ/SZA | 273 | 18.84 (6.39) | 19.41 (6.25) | 22.28 (6.36) | 0.034 | 1.807 | 0.758 | 2.905 | 0.003** | ||
| Healthy | 161 | 28.00 (2.21) | 26.31 (3.62) | 26.37 (3.56) | 0.002 | −0.251 | −0.977 | 0.496 | 0.501 | ||
Abbreviations: SWM, CANTAB Spatial Working Memory (Errors); SZ/SZA, Schizophrenia/Schizoaffective Disorder; Broad, broad sense psychosis diagnosis of bipolar disorder with psychotic features, major depressive disorder with psychotic features, or psychosis not otherwise specified; includes SZ/SZA patients.
The r2 represents the percentage of variance for each neuropsychological test score explained by the genotype; B is regression coefficient; p-values uncorrected. Bold indicates significance at P<0.05, *P<0.05 and **P<0.01.