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. 2017 Sep 21;14(6):6969–6975. doi: 10.3892/ol.2017.7021

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Figure 5. — Restoration of ADAM9 expression abrogates the suppressive effects of miR-154 on breast cancer cells. (A) Western blot analysis of ADAM9 protein expression levels in MCF-7 and MDA-MB-231 cells transfected with an ADAM9 vector or a blank vector control. *P<0.05 compared with blank vector. (B) ADAM9 overexpression abrogated the inhibition of proliferation in MCF-7 and MDA-MB-231 cells transfected with an miR-154 mimic. *P<0.05 compared with miR-154 mimic alone. (C) ADAM9 reversed the inhibition of migration and invasion in MCF-7 and MDA-MB-231 cells transfected with an miR-154 mimic (magnification, ×200). ADAM9, ADAM metallopeptidase domain 9; miR, microRNA; NC, negative control.

Figure 5. — Restoration of ADAM9 expression abrogates the suppressive effects of miR-154 on breast cancer cells. (A) Western blot analysis of ADAM9 protein expression levels in MCF-7 and MDA-MB-231 cells transfected with an ADAM9 vector or a blank vector control. *P<0.05 compared with blank vector. (B) ADAM9 overexpression abrogated the inhibition of proliferation in MCF-7 and MDA-MB-231 cells transfected with an miR-154 mimic. *P<0.05 compared with miR-154 mimic alone. (C) ADAM9 reversed the inhibition of migration and invasion in MCF-7 and MDA-MB-231 cells transfected with an miR-154 mimic (magnification, ×200). ADAM9, ADAM metallopeptidase domain 9; miR, microRNA; NC, negative control.