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. 2017 Oct 18;36(22):3309–3324. doi: 10.15252/embj.201796685

Figure 3. BSP exhibits a dose‐dependent inhibition of Maxi‐Cl in C127 cells.

Figure 3

  1. A PGT inhibitor, BSP, reversibly blocks Maxi‐Cl currents in outside‐out and inside‐out patches.
  2. BSP effects are dose dependent with IC50 = 7.4 ± 0.5 and 7.8 ± 1.9 for inside‐out patches at +25 mV and −25 mV, respectively, and IC50 = 6.8 ± 0.6 μM for outside‐out patches at +25 mV (n = 5). Error bars, SEM.
  3. Flickery events recorded in the presence of BSP in excised patches at both +25 mV and −25 mV.