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. 2017 Sep 28;36(22):3325–3335. doi: 10.15252/embj.201797609

Figure 2. BCAR4/ GLI2‐mediated YAP‐dependent glycolysis.

Figure 2

  • A–C
    Overexpression of BCAR4/GLI2 induced glucose uptake (A), lactate production (B), and medium acidification (C) in MDA‐MB‐231 and MDA‐MB‐468 (mean ± s.d., n = 3 biological replicates, Student's t‐test).
  • D, E
    Downregulation of BCAR4/GLI2 rescued the YAP‐5SA‐induced glucose uptake (D) and lactate production (E) in YAP‐5SA‐overexpressing HEK293A cells (mean ± s.d., n = 3 biological replicates, Student's t‐test).
  • F, G
    Overexpression of BCAR4/GLI2 rescued the decrease in glucose uptake (F) and lactate production (G) in YAP knockdown MCF10A cells (mean ± s.d., n = 3 biological replicates, Student's t‐test).
  • H
    Graphic illustration of BCAR4/GLI2 signaling in YAP‐regulated glycolysis.