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. 2017 Sep 28;36(22):3325–3335. doi: 10.15252/embj.201797609

Figure 4. Depletion of BCAR4 impaired YAP‐dependent tumorigenesis.

Figure 4

  • A–C
    Schematic illustration of LNA injection. 10 days after bearing breast tumors, nude mice were injected with scrambled LNA or BCAR4 LNA (25 mg/kg) every other day for three times (A). After 5 weeks, the tumors were excised and tumor weights (B) and bidimensional tumor measurements (C) were assessed (mean ± s.d., n = 5 tumor samples, Student's t‐test).
  • D
    Expression of BCAR4 was detected in the indicated xenograft tumors by quantitative PCR (mean ± s.d., n = 3 biological replicates, Student's t‐test).
  • E
    Representative immunohistochemical images of xenograft tumors are shown. Scale bar, 200 μm.
  • F–I
    The relative intensities of immunohistochemical staining (E) were quantified by Image‐pro plus 6.0 software (Media Cybernetics) (mean ± s.d., n = 3 biological replicates, Student's t‐test).