Table 2.

Correlation of Metabolic Risk Factors With Urinary F2-IsoP and its Major Metabolite

Metabolic Risk Factor	Urinary F2-IsoP (ng/mg Cr) (n = 65)	P Value	Urinary F2-IsoP Metabolite (ng/mg Cr) (n = 64)	P Value
Age (y)	0.28	0.0241a	0.10	0.4220
Weight (kg)	−0.28	0.0261a	0.02	0.9009
BMIb (kg/m2)	−0.09	0.4787	0.21	0.1035
Body composition
LBM (kg)	−0.46	0.0001c	−0.33	0.0076c
LBM (%)	−0.20	0.1126	−0.41	0.0008c
Total fat mass (kg) (n = 52; 51)	−0.04	0.7844	0.23	0.1013
Total body fatb (%)	0.18	0.1492	0.40	0.0011c
Trunk fat massb (g) (n = 63; 62)	0.01	0.9219	0.25	0.0471a
Waist circumference (cm)	−0.06	0.6319	0.11	0.4054
Hip circumference (cm) (n = 64; 63)	−0.07	0.5637	0.23	0.0712
Waist:hip ratio (n = 64; 63)	−0.01	0.9234	−0.13	0.3014
BMC (g) (n = 50; 49)	−0.58	<0.0001c	−0.40	0.0043c
BMD (g/cm2) (n = 51; 50)	−0.65	<0.0001c	−0.30	0.0358a
Fasting glucoseb (mg/dL)	0.23	0.0706	0.03	0.8180
GDR (mg/min/kg LBM) (n = 63; 62)	−0.01	0.9423	0.003	0.9798
Carbohydrate oxidation rateb (kcal/day/kg LBM)	−0.001	0.9928	−0.03	0.8379
Fat oxidation rate (kcal/day/kg LBM) (n = 64)	−0.07	0.5922	−0.01	0.9193
Lipid markers
Triglycerides (mg/dL)	0.36	0.0031a	0.23	0.0711
Total cholesterolb (md/dL)	0.32	0.0096c	0.11	0.4079
LDL-cholesterol (mg/dL) (n = 64; 63)	0.23	0.0670	0.08	0.5478
HDL-cholesterolb (mg/dL)	0.04	0.7331	−0.18	0.1580
Systolic blood pressure (mm Hg)	0.13	0.2924	0.07	0.5868
Diastolic blood pressure (mm Hg)	0.13	0.3228	−0.13	0.3027

All correlations are Pearson’s correlation coefficients, unless indicated as Spearman correlation coefficients. Metabolic parameters were otherwise normalized with natural log transformations as appropriate. All values for the urinary isoprostane and its metabolite are natural log-transformed, unless otherwise indicated for Spearman correlation.

^aP < 0.05.

^bSpearman correlation coefficient.

^cP < 0.01.