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. 2017 Nov 2;1(11):1372–1385. doi: 10.1210/js.2017-00262

Table 2.

SSB Consumption and Risk of T2DM

Author Cohort/Location Participants
Average Follow-up Period Mean SSB Intake/d Risk of T2DM P Value for Trend Confounder Adjustment
N Age (Mean/Range), y Sex
De Koning et al. (42) HPFS; United States 40,389 (2680 developed diabetes) 40–75 M and F 20 y 887 mL/d HR, 1.25 (95% CI, 1.11–1.39) vs nonconsumers <0.01 Yes
Fagherazzi et al. (5) E3N study; France 66,118 52.6 ± 6.6 F 14 y 328.3 mL/d HR, 1.34 (95% CI, 1.05–1.71) vs nonconsumers 0.0002 Yes
The InterAct Consortium (37) EPIC database; 8 European countries 11,684 41–62 M and F 16 y <1 glass/mo to ≥1 glass/d HR, 1.22 (95% CI, 1.09–1.38) increase with one serving of SSB 0.86 Yes
Lofvenborg et al. (10) ESTRID study; Sweden 2864 45.2–71.8 M and F 5 y None to >2 servings/d OR increased to 2.39 (95% CI, 1.39–4.09); 20% increase with each additional serving Not available Yes
Maki et al. (43) 43 (n = 21 for SSB) 53.8 ± 2.1 M and F 14 wk 2160 ± 91.7 kcal/d SSB consumption is associated with less favorable values for T2DM risk Not available Yes
Palmer et al. (39) Black Women’s Health Study, United States 43,960 29–49 F 10 y <1 to ≥2/d Incident rate ratio was 1.51 (95% CI, 1.31–1.75) vs fruit juice 0.002 Yes
Sakurai et al. (41) Japan 2037 35–55 M 7 y 0 to ≥1 serving/d HR, 1.34 (0.72– 2.36), ≥ 1 serving/d vs rare/never 0.424 Yes
Teshima et al. (44) Mihama Diabetes Prevention Study; Japan 93 40–69 M and F 3.6 ± 0.2 y No intake to daily intake OR, 3.26 (95% CI, 1.17–9.06) vs no SSB intake 0.001 No
Odegaard et al. (36) Singapore 43,580 45–74 M and F 5.7 y None to 2–3 servings/wk RR, 1.42 (95% CI, 1.25–1.62) vs no SSB intake P-trend < 0.0001 Yes

Abbreviations: CI, confidence interval; ESTRID, Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes; E3N, Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale; F, female; HPFS, Health Professionals Follow-up Study; HR, hazard ratio; M, male; OR, odds ratio; RR, relative risk.