Table 2.
Summary of IPA of CVB4-Infected Islets vs Mock-Infected Islets
| Top canonical pathways | ||
| Name | P value | Overlap |
| Interferon signaling | 7.45E-10 | 16.7% (6/36) |
| Antigen presentation pathways | 7.35E-08 | 13.2% (5/38) |
| T1D signaling | 1.28E-05 | 4.7% (5/106) |
| Activation of IRF by cytosolic PRRs | 2.57E-05 | 6.7% (4/60) |
| Th1 pathway | 3.44E-05 | 3.8% (5/130) |
| Top upstream regulators | ||
| Upstream regulator | P value of overlap | Predicted activation |
| IFNG | 1.12E-22 | Activated |
| IFNL1 | 6.98E-22 | Activated |
| MAPK1 | 9.78E-19 | Inhibited |
| IFNA2 | 4.17E-16 | Activated |
| IFNB1 | 3.95E-14 | Activated |
| Top diseases and bio functions | ||
| Diseases and disorders | ||
| Name | P value | Number of molecules |
| Antimicrobial response | 2.85E-03–4.91E-12 | 11 |
| Inflammatory disease | 2.19E-02–4.91E-12 | 28 |
| Dermatological diseases and conditions | 1.14E-02–2.04E-09 | 21 |
| Organismal injury and abnormalities | 2.19E-02–2.04E-09 | 53 |
| Immunological disease | 2.18E-02–1.79E-08 | 32 |
| Molecular and cellular functions | ||
| Name | P value | Number of molecules |
| Cell signaling | 1.08E-02–2.20E-07 | 14 |
| Cell death and survival | 2.13E-02–3.53E-07 | 23 |
| Cellular growth and proliferation | 1.98E-02–1.05E-06 | 26 |
| Cellular movement | 2.25E-02–2.94E-05 | 17 |
| Carbohydrate metabolism | 1.70E-02–3.26E-05 | 4 |
| Physiological system development and function | ||
| Name | P value | Number of molecules |
| Cardiovascular system development and function | 1.85E-02–2.17E-05 | 10 |
| Organismal development | 1.85E-02–2.17E-05 | 12 |
| Tissue development | 1.85E-02–6.40E-05 | 10 |
| Tissue morphology | 1.98E-02–6.92E-03 | 7 |
| Hematological system development and function | 1.98E-02–1.21E-04 | 11 |
| Top regulator effect networks | ||
| ID regulators | Diseases and functions | Consistency score |
| BTK, EIF2AK2, IFNA2, IFNG, IFNL1, PRL, SOCS1, TLR7, TLR9 | Relapsing-remitting multiple sclerosis and replication of virus replicon | 33.5 |
| JAK1, NLRC5, TGM2 | Viral infection | 2.774 |
| MAPK1 | Viral infection | −1.664 |
| IFNA2 | Cell death | −2.333 |
| IL1RN | Cell death | −2.828 |
| Top networks | ||
| ID-associated network functions | Score | |
| Antimicrobial response, inflammatory response, infectious diseases | 40 | |
| Cellular growth and proliferation, development, cellular development, and lymphoid tissue structure | 14 | |
| Cell signaling, cancer, organismal injury, and abnormalities | 8 | |
| Developmental disorder, hereditary disorder, metabolic disease | 2 | |
| Cellular assembly and organization, gastrointestinal disease, and hepatic system disease | 2 | |
Abbreviations: IRF, IFN-regulatory factor; PRR, pattern recognition receptor; Th1, T helper 1.