12. Mefloquine versus chloroquine; characteristics of included studies for safety.

Study ID	Participants	Number enrolled	Method of adverse event monitoring	Significant exclusions for psychiatric side effects	Trial duration	Source of funding
RCT s
Boudreau 1991	Thai gem miners	501	Interview with study personnel	None	14 weeks	USA Army
Boudreau 1993	USA soldiers	359	Interview with study personnel and computerised questionnaire	"M edical history of psychiatric or neurological problems within the last 5 years"	13 weeks	Not mentioned
Bunnag 1992	Thai adult mal es	605	Interview with study personnel	None	24 weeks	Roche
Salako 1992	Nigerian adult males	567	Interview with study personnel	None	24 weeks	Not mentioned
Sossouhounto 1995	Ivory C oast adult males	500	" Access to the village health centre. Clinical examination with study personnel"	None	20 weeks	Not mentioned
Steketee 1996	Pregnant Malawian women	4220	Interview with study personnel	None	Monitored from enrolment to delivery	Government funding
Non‐randomised studies
	Participants	Number enrolled	Method of adverse event monitoring	Factors influencing drug allocation	Duration of travel	Source of funding
Albright 2002	USA travelling children aged < 13 years	177	Interview with study personnel	Allocation based on guidelines and participant preference	Various, not specified	Not mentioned
Corominas 1997	Spanish short‐term adult travellers	1054	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	Maximum 6 weeks	Not mentioned
Cunningham 2014	UK Foreign and Commonwealth Office staff	327	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	0 to 36 months	Not mentioned
Hill 2000	USA short‐term travellers	822	Interview with study personnel	Allocation based on guidelines and participant preference	Median 19 days, up to 90 days	Not mentioned
Korhonen 2007	Peace Corps volunteers	2701	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	≥ 6 months	Two staff employed by Peace Corps
Laver 2001	Adult short‐term travellers	660	Participant self‐reported questionnaire	No information available	93% < 4 weeks	" No financial interests to disclose"
Laverone 2006	Italian short‐term travellers	1176	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	> 90% 0 to 30 days	Not mentioned
Lobel 2001	Adult short‐term travellers	5626	Participant self‐reported questionnaire	No information available	M ost < 5 weeks	" No financial interests to disclose"
Napoletano 2007	Italian short‐term travellers	1906	Telephone interview	Allocation based on guidelines and participant preference	Mean 2 weeks, range 0 to > 35 days	Not mentioned
Petersen 2000	Danish travellers	4154	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	Various, 65% < 3 weeks	Not mentioned
Rietz 2002	Swedish short‐term travellers	491	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	" Most" 2 to 4 weeks	Not mentioned
Steffen 1993	Adult short‐term travellers	145,003	Participant self‐reported questionnaire	No information available	98% stayed between 1 and 4 weeks	Roche
Stoney 2016	USA short‐term travellers	370	Participant self‐reported questionnaire	Allocation based on guidelines and participant preference	Median duration 13 days	Government funding
Tan 2017	Peace Corps volunteers	8931	Participant self‐reported questionnaire	No information available	Various, not specified	No dedicated funding
Waner 1999	Adult short‐term travellers	3051	Participant self‐reported questionnaire	No information available	A pprox. 6 weeks	" not funded by an external body"