13. Mefloquine versus chloroquine; quality of adverse events reporting.

Study ID	Harms predefined¹	Description of ascertainment technique²	Active or passive monitoring?³	Prospective or retrospective data collection?
RCTs
Boudreau 1991	Adequate	Adequate	Active	Prospective
Boudreau 1993	Adequate	Adequate	Active	Prospective
Bunnag 1992	Inadequate " Adverse events were defined clinically, and starting week 14, volunteers reporting adverse events were interviewed by members of the hospital team"	Adequate	Active	Prospective
Salako 1992	Inadequate " Particular attention was paid to complaints such as fever, chills, malaise, nausea and vomiting, rashes and other symptoms and signs that could be regarded as adverse events." Comment: no clear definition of adverse events wa s provided	Adequate	Active	Prospective
Sossouhounto 1995	Inadequate " Participants had access to a village health center, where they could notify personnel of any malaise or side effects"	Unclear " Clinical examinations and parasitologic tests were performed every 4 weeks"	Passive	Prospective
Steketee 1996	Adequate	Adequate	Active	Prospective
Cohort studies
Albright 2002	Adequate	Adequate	Passive	Retrospective
Corominas 1997	Inadequate Comment: insufficient information wa s provided about the questions that travellers were asked	Adequate	Active	Retrospective
Cunningham 2014	Inadequate Comment: questionnaire included a targeted list of side effects, including " other psychological problems" . What was included within this was not defined	Adequate	Passive	Unclear Comment: questionnaire was performed while participants were still taking chemoprophylaxis medication, although 75% were non‐compliant
Hill 2000	Inadequate Comment: insufficient information wa s provided about the questions that travellers were asked	Adequate	Active	Retrospective
Korhonen 2007	Adequate	Adequate	Passive	Unclear Comment: No information wa s provided regarding the timing of the questionnaire during treatment
Laverone 2006	Adequate	Adequate	Passive	Retrospective
Lobel 2001	Inadequate "Travellers… were given a questionnaire that asked for... adverse health events attributed to those drugs"	Adequate	Passive	Unclear Comment: information was collected at the airport, when travellers should still have been taking the prophylactic regimen
Napoletano 2007	Unclear Comment: adverse events were categorised on a scale of one to four, but it is unclear whether and how causality was assessed	Adequate	Active	Retrospective
Petersen 2000	Inadequate Comment: i t wa s unclear whether the questionnaire implied causality to the drug regimen	Adequate	Active	Retrospective
Rietz 2002	Adequate	Adequate	Active	Retrospective
Steffen 1993	Adequate	Adequate	Passive	Unclear Comment: information was collected during the flight home, when travellers should still have been taking the prophylactic regimen
Stoney 2016	Inadequate Comment: insufficient information provided on the questions that travellers were asked	Inadequate Comment: n o information wa s reported on how adverse events were ascertained	Active	Prospective
Tan 2017	Adequate	Adequate	Active	Retrospective
Waner 1999	Inadequate Comment: insufficient information provided on the questions that travellers were asked	Adequate	Passive	Unclear Comment: information was collected during the flight home, when travellers should still have been taking the prophylactic regimen

1. Were harms pre‐defined using standardised or precise definitions?

2. Was ascertainment technique adequately described?

3. Monitoring classed as 'active' if it occurred at set time points during treatment.

For full description of analysis methods, see Table 4.