. 2017 Mar 23;1(5):431–435. doi: 10.1210/js.2017-00054

Table 2.

Summary of Reported Cases of Biotin Interference in Thyroid Function Tests

Reference	Age	Daily Biotin Dose	Thyroid Function Tests on Biotin				Assay Method(s)	Consequences	Thyroid Function Tests After Discontinuing Biotin^a
Reference	Age	Daily Biotin Dose	TSH, mIU/L	fT4, pmol/L	fT3, pmol/L	Anti-TSH Receptor Ab, IU/L	Assay Method(s)	Consequences	TSH, mIU/L	fT4, pmol/L	fT3, pmol/L	Anti-TSH Receptor Ab, IU/L
Elston et al. (5)	3 d	10 mg	38.4	77	ND	ND	Boehringer Mannheim ES700	Delay in treating hypothyroidism	140, >209	16.3, 11	ND	ND
Elston et al. (5)	3 y	40 mg	0.62	15.5	4.5	ND	Roche Cobas e601	None	3.96	75.9	14	ND
Wijeratne et al. (4)	1 wk	30 mg	3.75	>77.7	24.9	ND	Beckman DxI	None	N	N	N	ND
Barbesino (1)	55 y	300 mg	0.02	>100.4	ND	36	Elecsys, Roche	¹²³I thyroid scan	0.78	18	ND	<1.75
Elston et al. (5)	63 y	300 mg	0.02	>100, 69	11.6	>40	Roche & Beckman	None	1.93, 1.9	14, 17	4.4	2.3
Kummer et al. (6)	9 y	10 mg/kg	0.05	80.3	ND	38.6	NR	None	1.8	20.3	ND	<0.3
Kummer et al. (6)	2 y	14 mg/kg	0.02	>100	ND	>40	NR	Antithyroid drugs	3.75	21.9	ND	ND
Kummer et al. (6)	2 y	15 mg/kg	0.04	>100	ND	>40	NR	Antithyroid drugs	6.07	14.9	ND	0.7
Kummer et al. (6)	5 mo	2 mg/kg	0.02	>100	ND	>40	NR	None	2.2	14.5	ND	1
Kummer et al. (6)	1 mo	7 mg/kg	0.08	>100	ND	>40	NR	None	8.12	23.7	ND	0.4
Kummer et al. (6)	1 mo	8 mg/kg	0.03	>100	ND	>40	NR	Antithyroid drugs	2.87	24.6	ND	<0.3
Trambas et al. (3)	NR	300 mg	0.02	>100	17.3	ND	NR	NR	1.3	11.3	4.5	ND
Simó-Guerrero et al. (8)	38 y	300 mg	0.07	50.1	ND	ND	Roche, Modular E170	None	2.34	13.3	ND	ND
Bülow Pedersen et al. (9)	4 d	5 mg	0.1	ND	ND	ND	NR	None	4.3	ND	ND	Negative
Minkovsky et al. (10)	74 y	300 mg	0.02	>100.4	ND	ND	Roche	¹²³I thyroid scan	4.54	19.3, 21.9	ND	ND

Abbreviations: fT3, free triiodothyronine; ND, not done; NR, not reported.

^{^a}

Results of thyroid functions tests after using a different assay are in bold.