Table 1.
Main Features of Two Patients With Prolactin-Secreting Microadenomas at Diagnosis
| Patient 1 (P1) | Patient 2 (P2) | Normal Range | |
|---|---|---|---|
| Age, y | 32 | 36 | — |
| Menstrual cycle | Amenorrheaa | Amenorrheab | Regular (27–32 days) |
| Galactorrhea | Yes | Yes | — |
| Microadenoma at pituitary MRI | 5-mm diameter intrasellar | 6-mm diameter intrasellar | — |
| Prolactin, ng/mL | 94–102c | 98–112c | 9–20 |
| FSH, IU/L | 4.2 | 4.9 | (3.1–7.6)d |
| LH, IU/L | 3.9 | 2.1 | (2.9–7.8)d |
| Estradiol, pg/mL | 21 | 17 | (22–97)d |
| Progesterone, ng/mL | 0.2 | 0.3 | (4.9–14.4)e |
| Inhibin B, pg/mL | 49 | 28 | (29–126)d |
| Cortisol, ng/mLe | 108/265f | 124/209f | (89–220)/(198–336)f |
| Free T4 (pmol/L)/TSH (mIU/L) | 16.8/2.7 | 15.2/1.9 | (10.4–21)/(0.6–4.4) |
| IGF1, µg/L | 273 | 232 | (169–311)g |
| DHEAS, ng/mL | 1954 | 1386 | (679–3993)g |
To convert estradiol in pg/mL to pmol/L, multiply by 3.671. To convert the prolactin values in ng/mL to mIU/L, multiply by 21.3. For DHEAS, to convert ng/mL to nmol/L, multiply by 2.714.
Abbreviations: DHEAS, dehydroepiandrosterone sulfate; FT4, free thyroxine; IGF1, insulin-like growth factor-1; MRI, magnetic resonance imaging; TSH, thyroid stimulating hormone.
a
Since 6 months.
b
Since 11 months.
c
Range (different measures and after exclusion of macroprolactinemia).
d
In the early follicular phase.
e
In the normal luteal postovulatory phase.
f
Basal/peak under hypoglycemia challenge test.
g
In healthy 30- to 40-year-old women.