FIG 3.

Changes in the total B cells as well as naive versus memory B cells from circulation, lymph nodes, and intestine over the course of progressive SIVsab infection of AGMs and nonprogressive SIVsab infection of PTMs. (A to C) Fold increase of the absolute counts of total B cells in peripheral blood (A) and in the frequency of B cells from the lymph nodes (B) and intestine (C) in AGMs and PTMs. (D to O) Fold increase of naive (D to F), resting memory (G to I), activated memory (J to L), and tissue-like memory (M to O) B cells from circulation (left), lymph nodes (middle), and intestine (right) in AGMs and PTMs. Dotted lines mark the baseline levels of total B cells and of the different cell subsets. The Mann-Whitney U test was used to assess significance. Error bars correspond to standard errors of the means. Significant changes from the preinfection baseline levels are indicated as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.001; and ****, P < 0.0001.