TABLE 1.

Nonparametric analysis of correlation of quantitated HIV DNA (total, integrated, or unintegrated) with IFN-γ production and with activating receptor-induced expression on NK cells after activation in vitro^a

Graphic representation, data set	Variable 1	Variable 2	Spearman ρ	P > |ρ|
Fig. 2	IFN-γ + (a)	I HIV DNA	−0.4858	0.0088*
	IFN-γ + (b)	I HIV DNA	−0.5101	0.0013*
	IFN-γ + (c)	I HIV DNA	−0.5831	0.0002*
Fig. 2, NS	IFN-γ + (a)	T HIV DNA	−0.5976	0.0013*
	IFN-γ + (b)	T HIV DNA	−0.4329	0.0190*
	IFN-γ + (c)	T HIV DNA	−0.4148	0.0486*
	IFN-γ + (a)	U HIV DNA	−0.2274	0.2851
	IFN-γ + (b)	U HIV DNA	0.0446	0.8286
	IFN-γ + (c)	U HIV DNA	−0.0887	0.7098
Fig. 3A	FI % NKp46 expression	I HIV DNA	−0.5536	0.0075*
	FI % NKp30 expression	I HIV DNA	−0.6873	0.0033*
Fig. 3B	IFN-γ + (a)	FI % NKp46 expression	0.7169	0.0130*
	FI % NKp30 expression	IFN-γ + (a)	0.7945	0.0035*
Fig. 3C	I HIV DNA	FI MFI for NKp46 expression	−0.6561	0.0205*
	I HIV DNA	FI MFI for NKp30 expression	−0.6333	0.0365*
	IFN-γ + (a)	FI MFI for NKp46 expression	0.8389	0.0024*
	IFN-γ + (a)	FI MFI for NKp30 expression	0.7939	0.0061*
Fig. 3, NS	FI % NKp46 expression	T HIV DNA	−0.6423	0.0032*
	FI % NKp30 expression	T HIV DNA	−0.6527	0.0039*
	FI % NKp46 expression	U HIV DNA	0.056	0.7117
	FI % NKp30 expression	U HIV DNA	−0.1989	0.1956
	T HIV DNA	FI MFI for NKp46 expression	−0.6555	0.0207*
	U HIV DNA	FI MFI for NKp46 expression	−0.487	0.0657
	T HIV DNA	FI MFI for NKp30 expression	−0.6872	0.0195*
	U HIV DNA	FI MFI for NKp30 expression	−0.5612	0.0724
Fig. 4A	IFN-γ + (a)	I HIV DNA	−0.6048	0.0003*
	IFN-γ + (b)	I HIV DNA	−0.4375	0.0053*
Fig. 4B	FI % NKp46 expression	I HIV DNA	−0.5954	0.0056*
	FI % NKp30 expression	I HIV DNA	−0.831	<.0001*
Fig. 4C	IFN-γ + (a)	I HIV DNA	−0.7185	0.0127*
	IFN-γ + (b)	I HIV DNA	−0.7219	0.0121*
Fig. 4D	FI % NKp46 expression	I HIV DNA	−0.0251	0.9489
	FI % NKp30 expression	I HIV DNA	−0.2523	0.5852
Fig. 4F	FI % NKp30 expression	% cytolysis	0.7107	0.0142*
Fig. 4, NS	IFN-γ + (a)	T HIV DNA	−0.5976	0.0013*
	IFN-γ + (b)	T HIV DNA	−0.4329	0.0190*
	FI % NKp46 expression	T HIV DNA	−0.5051	0.0231*
	FI % NKp30 expression	T HIV DNA	−0.5258	0.0250*
	IFN-γ + (a)	T HIV DNA (only PP)	−0.7165	0.0059*
	IFN-γ + (b)	T HIV DNA) (only PP)	−0.8988	<0.0001*
	FI % NKp46 expression	T HIV DNA (only PP)	0.0418	0.9149
	FI % NKp30 expression	T HIV DNA (only PP)	−0.1441	0.7578
	IFN-γ + (a)	U HIV DNA	−0.2274	0.2851
	IFN-γ + (b)	U HIV DNA	0.0446	0.8286
	FI % NKp46 expression	U HIV DNA	−0.2325	0.324
	FI % NKp30 expression	U HIV DNA	−0.3976	0.114
	IFN-γ + (a)	U HIV DNA (only PP)	0.1215	0.7219
	IFN-γ + (b)	U HIV DNA (only PP)	0.4014	0.221
	FI % NKp46 expression	U HIV DNA (only PP)	0.1187	7611
	FI % NKp30 expression	U HIV DNA (only PP)	0.3964	0.3786
	NKG2D expression on resting NK cells	I HIV DNA	−0.1258	0.4518
	NKG2D expression on resting NK cells	T HIV DNA	−0.1832	0.2516
	NKG2D expression on resting NK cells	U HIV DNA	0.0519	0.7603

^aNS, not shown; I, integrated DNA; T, total DNA; U, unintegrated DNA; IFN-γ + NK, % CD56⁺ IFN-γ⁺ NK cells; FI, fold increase; (a), after rhIL-12-plus-rhIL-15 activation; (b), NK cells after anti-NKp46 and anti-NKp30 MAb activation; (c), after anti-NKG2D and DNAM-1 activation. HIV DNA was reported as the number of copies/10e4 CD4 cells. Group composition refers to the group comparison in the respective figure (indicated in column 1), unless otherwise specified. Asterisks in the final column indicate ••••.