TABLE 2.
Influenza A virus tissue topography in experimentally inoculated chickens sacrificed on day 2 p.i. as revealed by immunohistochemistry
| Tissue type | Median scorea for animals infected with: |
|||||
|---|---|---|---|---|---|---|
| AR236 | C8 | C11 | C20 | C5 | C46 | |
| Endothelial cells (median for all organs) | 3.0 | 3.0 | 3.0 | 2.0 | 2.0 | 1.0 |
| Parenchymal cells (median for all organs) | 1.5 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Parenchymal cells | ||||||
| Lungs | 3.0 | 3.0 | 3.0 | 2.0 | 2.0 | 2.0 |
| Heart | 2.5 | 2.0 | 2.0 | 1.0 | 1.0 | 1.0 |
| Liver | 1.0 | 1.0 | 2.0 | 1.5 | 1.5 | 2.0 |
| Spleen | 2.0 | 1.0 | 1.5 | 1.0 | 1.0 | 1.0 |
| Brain | 2.0 | 1.0 | 0.5 | 1.5 | 1.0 | 1.0 |
| Kidneys | 1.5 | 1.0 | 0.5 | 0.0 | 0.0 | 0.5 |
| Pancreas | 1.0 | 0.0 | 0.5 | 0.5 | 0.0 | 0.5 |
| Cecum with cecal tonsils | 1.0 | 1.0 | 0.0 | 0.5 | 0.0 | 0.0 |
| Duodenum | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
a
The values represent the median score for all animals within each group. Scores are as follows: 0, no influenza A virus nucleoprotein immunoreactivity; 1, focal to oligofocal influenza A virus nucleoprotein immunoreactivity; 2, multifocal influenza A virus nucleoprotein immunoreactivity; 3, coalescing to diffuse influenza A virus nucleoprotein immunoreactivity.