Table 3.
Global data of countries affected by NTDs, drugs donated, burden of each disease, and number of patent families
| Neglected Tropical Diseases (PCT/IDM) | Number of countries | Disease burden | Preventive Chemotherapy/Intensified disease management | Effectiveness of current interventions | Total granted/patent families | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Incidence | Prevalence | DALYS | Prevention | Treatment | Resistance | Donated | Prevention | Treatment | |||
| Taeniasis | >75 | No data | No data | 503,000 | Praziquantel/Niclosamide through MDA, identification and treatment of cases, health education including hygiene and food safety, improved sanitation, improved pig husbandry, anthelmintic treatment of pigs, vaccination of pigs, Improved meat inspection and processing of meat products. |
Praziquantel/Niclosamide | Yes [40] | Yes | High | High | 48/231 |
| Trachoma (PCT) | 42 | No data | 3,557,122 | 279,200 | Azithromycin through MDA programs SAFE strategy |
Azithromycin, Tetracycline | Yes [41] | Yes | High | High | 514/2094 |
| Yaws (IDM) | 13 | No data | No data | No data | Azithromycin through MDA programs. Health education and improvement in personal hygiene are essential components of prevention. | Azithromycin Benzathine Penicillin |
Probably [42] | No | High | High | 203/880 |
PCT Preventive chemotherapy and transmission control
IDM innovative and intensified disease management
MDA mass drug administration
N/A not applicable
SAFE surgery for advanced disease, antibiotics to clear Chlamydia trachomatis infection, facial cleanliness, and environmental improvement to reduce transmission
Sources: 1) The disease burden disability adjusted life years (DALYS) (the sum of years lost due to premature death (YLLs) and years lived with disability (YLDs)), Incidence (the total number of cases of a given disease in a specified population at a designated time), and Prevalence (the number of new cases of a given disease during a given period in a specified population), values −2015 were obtained from Global Health Data Exchange [43] and [14], 2) The number of countries and drugs used (Preventive Chemotherapy and Transmission Control; and Innovative and Intensified Disease Management) were obtained from WHO fact sheets [44], 3) Data on number of patent families was retrieved from Patseer database, 4) Efficacy/effectiveness/efficiency notes were obtained from the Third WHO Report on Neglected Tropical Diseases [45]