Table 1.
MiRNAs present in the top-100 ranked candidate miRNAs that are known to be associated with diseases, as reported in the HMDD database. P-value is the result of the hypergeometric enrichment test
| MIM ID | Disease | Overlap | Total in HMDD | p-value | Known disease miRNAs |
|---|---|---|---|---|---|
| 150699 | leiomyoma | 2 | 3 | 0.012 | hsa-miR-106b, hsa-miR-93 |
| 109800 | bladder cancer | 6 | 27 | 0.006 | hsa-miR-17, hsa-miR-182, hsa-miR-200b, hsa-miR-200c, hsa-miR-20a, hsa-miR-27a |
| 143100 | huntington disease | 1 | 7 | 0.376 | hsa-miR-200c |
| 601665 | obesity | 2 | 7 | 0.091 | hsa-miR-17, hsa-miR-30e |
| 145500 | hypertension | 3 | 15 | 0.069 | hsa-let-7e, hsa-miR-17, hsa-miR-20a |
| 600634 | pituitary adenoma | 1 | 14 | 0.065 | hsa-miR-107 |
| 133239 | esophageal cancer | 8 | 51 | 0.017 | hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-miR-19a, hsa-miR-200c, hsa-miR-203, hsa-miR-29c, hsa-miR-98 |
| 181500 | schizophrenia | 17 | 29 | 2.19×10−13 | hsa-miR-106b, hsa-miR-137, hsa-miR-15a, hsa-miR-15b, hsa-miR-17, hsa-miR-181b, hsa-miR-195, hsa-miR-20b, hsa-miR-26b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30a, hsa-miR-30b, hsa-miR-30d, hsa-miR-30e, hsa-miR-9 |
| 603956 | cervical cancer | 2 | 3 | 0.023 | hsa-miR-20a, hsa-miR-424 |
| 155601 | melanoma | 34 | 130 | 8.97×10−14 | hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7 g, hsa-let-7i, hsa-miR-106a, hsa-miR-106b, hsa-miR-137, hsa-miR-15a, hsa-miR-15b, hsa-miR-16, hsa-miR-17, hsa-miR-181a, hsa-miR-182, hsa-miR-195, hsa-miR-196a, hsa-miR-19a, hsa-miR-19b, hsa-miR-200b, hsa-miR-200c, hsa-miR-20a, hsa-miR-20b, hsa-miR-218, hsa-miR-23b, hsa-miR-27b, hsa-miR-30a, hsa-miR-30b, hsa-miR-30d, hsa-miR-30e, hsa-miR-429, hsa-miR-506, hsa-miR-9, hsa-miR-93 |
| 151400 | leukemia | 6 | 26 | 0.009 | hsa-miR-17, hsa-miR-181a, hsa-miR-19a, hsa-miR-19b, hsa-miR-20a, hsa-miR-27a |
| 268210 | rhabdomyosarcoma | 2 | 7 | 0.112 | hsa-miR-106a, hsa-miR-29a |
| 104300 | alzheimer disease | 10 | 16 | 9.36×10−8 | hsa-miR-106b, hsa-miR-124, hsa-miR-125b, hsa-miR-128, hsa-miR-137, hsa-miR-17, hsa-miR-181c, hsa-miR-195, hsa-miR-20a, hsa-miR-9 |
| 256700 | neuroblastoma | 10 | 29 | 1.23×10−5 | hsa-miR-106b, hsa-miR-124, hsa-miR-128, hsa-miR-19a, hsa-miR-19b, hsa-miR-20a, hsa-miR-27b, hsa-miR-340, hsa-miR-9, hsa-miR-93 |
| 113970 | burkitt lymphoma | 5 | 10 | 2.05×10−4 | hsa-miR-17, hsa-miR-19a, hsa-miR-19b, hsa-miR-20a, hsa-miR-93 |
| 114500 | colorectal cancer | 26 | 120 | 3.04×10−8 | hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-miR-106a, hsa-miR-137, hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-182, hsa-miR-195, hsa-miR-19a, hsa-miR-19b, hsa-miR-200b, hsa-miR-200c, hsa-miR-20a, hsa-miR-218, hsa-miR-23a, hsa-miR-26a, hsa-miR-26b, hsa-miR-27b, hsa-miR-29a, hsa-miR-340, hsa-miR-497, hsa-miR-9, hsa-miR-93, hsa-miR-96 |
| 260350 | pancreatic cancer | 23 | 89 | 6.42×10−9 | hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7 g, hsa-let-7i, hsa-miR-106a, hsa-miR-128, hsa-miR-15a, hsa-miR-15b, hsa-miR-17, hsa-miR-181b, hsa-miR-182, hsa-miR-200a, hsa-miR-200c, hsa-miR-20a, hsa-miR-23a, hsa-miR-26a, hsa-miR-27a, hsa-miR-30c, hsa-miR-429, hsa-miR-96 |
| 211980 | lung cancer | 26 | 96 | 5.79×10−9 | hsa-let-7i, hsa-miR-106a, hsa-miR-181a, hsa-miR-181b, hsa-miR-181c, hsa-miR-182, hsa-miR-19b, hsa-miR-200b, hsa-miR-200c, hsa-miR-206, hsa-miR-23a, hsa-miR-25, hsa-miR-27b, hsa-miR-301a, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-30e, hsa-miR-32, hsa-miR-497, hsa-miR-9, hsa-miR-92a, hsa-miR-93, hsa-miR-96, hsa-miR-98 |
| 168600 | parkinson disease | 7 | 24 | 9.43×10−4 | hsa-miR-19b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c |
| 114480 | breast cancer | 41 | 170 | 1.96×10−13 | hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f, hsa-let-7 g, hsa-let-7i, hsa-miR-1, hsa-miR-106b, hsa-miR-137, hsa-miR-15a, hsa-miR-16, hsa-miR-181a, hsa-miR-181b, hsa-miR-182, hsa-miR-195, hsa-miR-19a, hsa-miR-19b, hsa-miR-202, hsa-miR-20b, hsa-miR-23a, hsa-miR-23b, hsa-miR-27b, hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-miR-302a, hsa-miR-302b, hsa-miR-302c, hsa-miR-302d, hsa-miR-30a, hsa-miR-30b, hsa-miR-30c, hsa-miR-30d, hsa-miR-340, hsa-miR-497, hsa-miR-519d, hsa-miR-520b, hsa-miR-9, hsa-miR-93, hsa-miR-96 |
| 236000 | lymphoma | 14 | 47 | 5.64×10−7 | hsa-miR-124, hsa-miR-133b, hsa-miR-15a, hsa-miR-17, hsa-miR-181a, hsa-miR-19a, hsa-miR-19b, hsa-miR-200b, hsa-miR-200c, hsa-miR-20a, hsa-miR-20b, hsa-miR-218, hsa-miR-26a, hsa-miR-29c |
| 155255 | medulloblastoma | 9 | 57 | 0.013 | hsa-miR-106a, hsa-miR-17, hsa-miR-181b, hsa-miR-182, hsa-miR-19a, hsa-miR-19b, hsa-miR-20a, hsa-miR-30a, hsa-miR-96 |
| 137215 | gastric cancer | 27 | 123 | 3.56×10−9 | hsa-let-7f, hsa-let-7 g, hsa-miR-106a, hsa-miR-107, hsa-miR-124, hsa-miR-130a, hsa-miR-17, hsa-miR-181a, hsa-miR-181b, hsa-miR-182, hsa-miR-195, hsa-miR-200b, hsa-miR-200c, hsa-miR-20a, hsa-miR-27a, hsa-miR-27b, hsa-miR-29a, hsa-miR-30b, hsa-miR-30c, hsa-miR-340, hsa-miR-372, hsa-miR-373, hsa-miR-429, hsa-miR-497, hsa-miR-503, hsa-miR-519a, hsa-miR-9 |