Table 1.
Demographic and clinical variables of MDR-TB patients registered in SITE-TB, Brazil, 2007–2013
| Variable | Included in study (1972) |
Excluded from study (2057) |
P- value |
|---|---|---|---|
| Sex | 0.06 | ||
| Female | 662 (34%) | 749 (36%) | |
| Male | 1310 (66%) | 1308 (64%) | |
| Age (mean) | 39.5 (SD 13.5) | 39.6 (SD 13.4) | 0.89 |
| Regimen | <0.01 | ||
| Individualized | 448 (23%) | 562 (27%) | |
| Standardized | 1524 (77%) | 1466 (72%) | |
| Unknown | 0 (0%) | 29 (1%) | |
| Ethnical group | |||
| Afro-Brazilian | 1213 (61%) | 1217 (59%) | 0.04 |
| Indigenous | 10 (1%) | 6 (1%) | |
| Caucasian | 728 (37%) | 795 (39%) | |
| Other | 21 (1%) | 39 (1%) | |
| TB Site | 0.80 | ||
| Pulmonary | 1916 (97%) | 1994 (97%) | |
| Extra-pulmonary | 21 (1%) | 21 (1%) | |
| Both | 35 (2%) | 42 (2%) | |
| AFB at baseline | |||
| Negative | 273 (14%) | 293 (14%) | <0.01 |
| Positive | 1650 (84%) | 1647 (80%) | |
| Unknown | 49 (2%) | 117 (6%) | |
| HIV | <0.01 | ||
| Positive | 180 (9%) | 201 (10%) | |
| Negative | 1721 (87%) | 1697 (83%) | |
| Unknown | 71 (4%) | 159 (7%) | |
| Cavity | 0.20 | ||
| Yes | 1554 (79%) | 1665 (81%) | |
| No | 396 (20%) | 371 (18%) | |
| Unknown | 22 (1%) | 21 (1%) | |
| Bilateral disease | <0.01 | ||
| Yes | 1283 (65%) | 1456 (70%) | |
| No | 667 (34%) | 580 (29%) | |
| Unknown | 22 (1%) | 21 (1%) | |
| Smoking | <0.01 | ||
| Yes | 156 (8%) | 231 (11%) | |
| No/unknown | 1816 (92%) | 1826 (89%) | |
| Alcohol use | 0.02 | ||
| Yes | 350 (18%) | 424 (21%) | |
| No/unknown | 1622 (82%) | 1633 (79%) | |
| Diabetes | 0.40 | ||
| Yes | 227 (12%) | 218 (11%) | |
| No/unknown | 1745 (88%) | 1839 (89%) | |
| DOT | <0.01 | ||
| Yes | 1558 (79%) | 1472 (72%) | |
| No/unknown | 414 (21%) | 585 (28%) | |
| Macro-region | 0.08 | ||
| North | 223 (11%) | 204 (9%) | |
| North-eastern | 580 (29%) | 560 (28%) | |
| Centre-west | 51 (3%) | 45 (2%) | |
| South-eastern | 856 (44%) | 981 (48%) | |
| South | 262 (13%) | 267 (13%) | |
| First DR-TB episode | <0.01 | ||
| Yes | 1643 (84%) | 1510 (73%) | |
| No | 284 (14%) | 456 (23%) | |
| Unknown | 45 (2%) | 91 (4%) | |
| Outcome | <0.01 | ||
| Cure* | 686 (35%) | 444 (22%) | |
| Complete treatment* | 489 (25%) | 430 (21%) | |
| Failure | 183 (9%) | 215 (10%) | |
| Loss to follow-up | 389 (20%) | 344 (17%) | |
| Death | 211 (9%) | 261 (13%) | |
| Unknown | 7 (1%) | 30 (1%) | |
| Transfer | 0 (0%) | 1 (0%) | |
| On treatment | 7 (1%) | 332 (16%) | |
| Six month culture conversion | <0.01 | ||
| Yes | 879 (45%) | 795 (39%) | |
| No | 206 (10%) | 210 (10%) | |
| Unknown | 887 (45%) | 1052 (51%) |
Abbreviation: DR-TB drug-resistant tuberculosis, AFB acid fast bacilli, SD standard deviation, DOT directly observed treatment
*Among included patients 10 had relapse episodes of MDR-TB