Table 1.
Patient characteristics (n = 135)
| Characteristic | Value |
|---|---|
| Median age (IQR) | 69 years (54–75) |
| Sex (female), n (%) | 69 (51%) |
| Pre-existing CNS disease, n (%) | 11 (8%) |
| Cerebral vascular disease | 6 (4%) |
| Encephalopathy | 2 (1%) |
| Othera | 3 (2%) |
| Renal function dysfunction | 108 (80%) |
| Creatinine clearance, median (IQR) | 26.5 (17–56) ml/min |
| History of alcohol use disorder, n (%) | 3 (2%) |
| Co-administered neurotoxic drug(s), n (%)b | 21 (16%) |
| Patient location, n (%) | |
| ICU | 60 (44%) |
| Non-ICU | 14 (10%) |
| Unreported | 61 (45%) |
CNS central nervous system
aOther pre-existing CNS diseases included encephalitis, spina bifida, dementia
bReported neurotoxic medications include amikacin, ciprofloxacin, metronidazole, cytarabine, cyclosporine, tacrolimus, phenytoin