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. 2017 Nov 14;16:197. doi: 10.1186/s12934-017-0801-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — In vivo thrombolytic activity by SD rats. The SD rats that reached the lowest blockage ratios after injection of the samples. a Test results of four cases (wild-type Sak, No. 4, 7 and 12 of PEG-Sak-C104R) by carotid artery blood flow with high blockage ratios (> 70%). b, c Embolism unblocking in SD rats treated with the wild-type Sak and PEG-Sak-C104R