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. 2017 Nov 14;10:267. doi: 10.1186/s13068-017-0957-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Application of the CRISPR system for manipulation of gene expression using dCas9. Different functional domains of transcriptional regulators can be fused to dCas9, which result in activation or repression of the target genes