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. 2017 Nov 7;28(23):3134–3155. doi: 10.1091/mbc.E17-04-0228

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© 2017 Chen, Ju, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Identification and characterization of GPIb mechanosensing mechanism. (A, B) Schematics of GPIb on the platelet membrane, highlighting the folded (−) and unfolded (+) LRRD and MSD. Ligand binding domain for VWF-A1 and other regions are indicated. (C–F) Illustrative BFP force traces showing zoom-in views of unfolding signatures in both ramping and clamping phases. (G, H) Illustrative analysis of GPIb-mediated single-platelet Ca²⁺ flux. Top, pseudo-colored images of intracellular Ca²⁺ in platelets in time sequences. Bottom, time courses of normalized intracellular Ca²⁺ intensity of the α (G) and β (H) types.