FIGURE 2:

Examples of SKBR3 breast cancer cells adhered at the bottom of a cell culture dish. (A) DIC image recorded with a 40× objective showing several adhered cells. Most cells exhibit membrane ruffles characterized as elongated membrane structures protruding from the plane of the membrane and often appearing at the cell periphery (e.g., at the arrows over cell 1). One cell does not contain membrane ruffles in its peripheral plasma membrane region and is identified as a flat cell (cell 2). (B) Fluorescence image of the same position as in A. The red fluorescence originates from the HER2-Affibody QD label.